White Cell and Platelet Disorders: Peripheral Blood Clues to Nonneoplastic Conditions (by LabCE)

2 P.A.C.E. contact hour(s)

(based on 676 customer ratings)

Authors: C. William Reiquam, M.D.; Elmer W. Koneman, M.D.
Reviewers: Leah Coppolino, MPH, MT(ASCP) and Stephen Hou, PhD, MB(ASCP),QCYM, MLS(ASCPi)

Course provided by LabCE.

This collection of informative case studies covers current topics in white cell and platelet disorders. Topics include leukemoid reactions, leukocytosis, intracellular granules, intra-cytoplasmic inclusion bodies, platelet satellitism, and more. Excellent for continuing education for clinical laboratory science professionals.

See more courses in: Hematology

Included In These Course Packages

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 2 hour(s)
Course number 578-095-20, approved through 9/30/2022
Course number 20-792908, approved through 9/1/2022


  • Recognize several peripheral white cell abnormalities and list the criteria necessary to request a morphological/clinical review.
  • Recognize and list the criteria by which a leukemoid reaction is differentiated from leukocytosis with a left shift.
  • Describe various intracellular white blood cell inclusions and correlate them with the metabolic, genetic, and reactive conditions with which they are associated.
  • Estimate platelet counts from peripheral blood smear scans and discuss erroneous automated platelet results.

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(based on 676 customer ratings)

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Course Outline

  • White Blood Cell Disorders and Platelets
    • Peripheral Smear Review Introduction
      • Peripheral Blood Smear Preparation
      • Evaluation Criteria: White Blood Cells and Platelets
      • Criteria for Performing a Manual Review of the Smear
      • Platelet Estimates
      • Additional Comments
    • Leukemoid Reaction and Toxic Changes
      • Leukemoid Reaction
      • Toxic Changes
      • Thrombocytosis Associated with Toxic Granulation
      • Case Study One
    • White Cell Nuclear and Cytoplasmic Abnormalities Related to Inherited Conditions
      • Pelger-Huet Anomaly
      • Chediak-Higashi Anomaly
      • Alder Anomaly
      • May-Hegglin Anomaly
      • WBC inclusions: Summary
      • Familial disorders: summary
      • Case Study Two: Follow-up
    • Miscellaneous Granulocytic Cells
      • Eosinophils
      • Basophils
    • Non Granulocytic White Blood Cells
      • Disorders and Diseases Associated With Increased Monocytes
      • Case Study Three
      • Case Study Four
      • Case Study Five
      • Multiple Myeloma
      • Smudge Cells
    • Platelets
      • Giant Platelets
      • Thrombocytopenia
      • Pseudo-thrombocytopenia
      • Thrombocytosis
  • References
      • References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical laboratory professionals, clinical laboratory science students and instructors of hematology.

General Information: This program provides several outstanding interactive case studies, which cover pertinent topics in white cell and platelet disorders. Numerous excellent photomicrographs enhance the text, and interactive questions help the student master the material.

Author Credentials: C. William Reiquam, MD (1923-2015) was a clinical professor of pathology in the School of Medicine, University of Colorado. One of his areas of expertise was hematology.

Author Credentials: Elmer W. Koneman M.D. is Professor Emeritus, Department of Pathology, University of Colorado School of Medicine. Residing in Breckenridge,CO, Dr. Koneman is a Board Certified Pathologist, former full Professor of Pathology University of Colorado School of Medicine. He is author of numerous journal articles and books.

Reviewer Credentials: Leah Coppolino, MPH, MT(ASCP) is the Director or Sales at MediaLab. Prior to joining MediaLab, Leah was the Director of the Clinical Laboratory Science Program at St. Christopher’s Hospital for Children in Philadelphia, Pennsylvania. She holds a Master’s Degree in Public Health from Thomas Jefferson University.

Reviewer Credentials: Stephen Hou has been involved in training medical laboratory scientists at NAACLS accredited programs for many years. With his specialist credential in cytometry, he also loves to study blood cell morphology. He is currently teaching various subjects in biomedical sciences at UW Milwaukee.

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Course provided by LabCE.
Auer Rod Blast 1.JPG

Auer Rod2.JPG

Bacteria-Band Neutrophil.JPG

Dimorphic RBC 3.JPG

Chediak 3.JPG

toxic gran_thrombocytosis

WBC inclusions

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