Detection and Management of Preeclampsia: Current Laboratory Testing and Emerging Biomarkers (by LabCE)

2 P.A.C.E. contact hour(s)

(based on 148 customer ratings)

Author: David J. Moffa, PhD
Reviewer: Jenny Camele, MT(ASCP)

Course provided by LabCE.

Preeclampsia (PE) is a multisystem, transient disorder of pregnancy, which affects 5-10% of pregnant women (usually during their first pregnancy). This course defines preeclampsia (PE) and discusses its prevalence, characteristics, signs, and symptoms. Pathophysiology, causes, treatment, and prevention are presented in this course along with the laboratory tests used in the diagnosis of preeclampsia.

See more courses in: Clinical Chemistry / Urinalysis / Toxicology

Included In These Course Packages

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 2 hour(s)
Course number 578-031-20, approved through 4/30/2022
Florida Board of Clinical Laboratory Personnel Credit Hours - General (Clinical Chemistry/UA/Toxicology): 2 hour(s)
Course number 20-773632, approved through 9/1/2020

Objectives

  • Define preeclampsia (PE) and discuss its prevalence, characteristics, signs, and symptoms.
  • Identify the characteristics of mild and severe PE as well as the relationship to the HELLP Syndrome.
  • Define the risk factors for PE and differentiate between eclampsia and the HELLP Syndrome.
  • Describe the pathophysiology of PE, its cause, treatment, and prevention.
  • Describe the main triggers used to diagnose PE.
  • Identify laboratory tests used to assist in the diagnosis of PE.
  • Define and describe angiogenesis relative to its possible role in PE and associated pro-angiogenic and anti-angiogenic factors.
  • Describe the various potential biomarkers for identifying pregnant women at risk for PE.
  • Identify assay methods available for several potential biomarkers.

Customer Ratings

(based on 148 customer ratings)

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Course Outline

  • Background and Overview of Preeclampsia
      • Background and Overview
  • Classification and Characteristics of Preeclampsia
      • Classification and Characteristics of Preeclampsia (PE)
      • HELLP Syndrome
  • Risk Factors for Preeclampsia
      • Risk Factors for Preeclampsia (PE)
  • Pathophysiology of Preeclampsia
      • Pathophysiology of Preeclampsia (PE)
      • Doppler Ultrasonography of Uterine Arteries
  • Treatment and Prevention
      • Treatment and Management of Preeclampsia (PE)
      • Treatment and Management of PE, continued
      • Treatment and Prevention (Aspirin Usage)
      • Postpartum PE
  • Current Laboratory Testing Used for PE Workup
      • Laboratory Tests Used for PE Workup: Urine and Serum Chemistry
      • Laboratory Tests Used for PE Workup: Hematology and Coagulation
  • Emerging Biomarkers for Preeclampsia
      • Emerging Biomarkers to Identify Risk for Preeclampsia (PE)
      • Angiogenesis and Angiogenic Biomarkers
      • Table I: Circulating Levels of Angiogenic Biomarkers in Preeclampsia (PE)
      • Table II: Circulating Levels of Other Potential Biomarkers in Preeclampsia (PE).
      • Laboratory Methods for Quantitation of Biomarkers Used for Determining Risk of PE
  • Summary and Conclusions
      • American College of Obstetricians and Gynecologists (ACOG) Current Guidelines for Identifying Preeclampsia
      • Summary and Conclusions on the Clinical Use of Biomarkers for Diagnosing and Predicting Risk for Developing PE
  • References
      • References

Additional Information

Level of instruction: Intermediate

Intended Audience: Medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for medical laboratory science students and pathology residents.

Author information: David Moffa, PhD, has over 30 years of experience in the health care industry as an executive manager, clinical laboratory director, and medical laboratory scientist. He is currently a technical consultant for Kentmere Healthcare, Wilmington, DE, and until his retirement, was the Regional Director for LabCorp, Inc. He holds a PhD in medical biochemistry from the School of Medicine, West Virginia University.

Reviewer information: Prior to her retirement in 2012, Jenny Camele was employed by Laboratory Corporation of America as the manager of customer service operations for the Fairmont West Virginia Region and a Quality Assurance committee member. She holds a Bachelor of Science degree in Medical Technology from West Virginia University.

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