Erythrocyte Inclusions (by LabCE)

2 P.A.C.E. contact hour(s)

(based on 1,458 customer ratings)

Marjorie A. Spahn, MT (ASCP); Marybeth Fannon, MA, MT (ASCP)
Reviewer: Rory Huschka, M.Ed., MT(ASCP)

Course provided by LabCE.

This course describes and richly illustrates various erythrocyte inclusions, including basophilic stippling, Cabot rings, Pappenheimer bodies, siderotic granules, and Howell-Jolly bodies, making it productive for CE, exam reviewing, and cross training.

See more courses in: Hematology

Included In These Course Packages

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 2 hour(s)
Course number 578-098-20, approved through 10/31/2022
Course number 20-795086, approved through 9/1/2022


  • Identify erythrocyte inclusions that may be observed on a Wright or Wright-Giemsa stained peripheral blood smear.
  • Identify erythrocyte inclusions that require staining methods other than Wright or Wright-Giemsa stain to be visualized on a peripheral blood or bone marrow smear.
  • Discuss the composition and formation of various erythrocyte inclusions.
  • Identify diseases or disorders associated with various erythrocyte inclusions.

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(based on 1,458 customer ratings)

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Course Outline

  • Introduction to erythrocyte inclusions
      • What are Erythrocyte Inclusions?
  • Characteristics of polychromatophilic red cells (Reticulocytes)
      • Reticulocytes
      • Normal Erythrocytes
      • Polychromatophilic Red Blood Cells (RBCs)
      • Polychromatophilic Cells, continued
      • Stress Reticulocytes
  • Characteristics of Basophilic Stippling
      • Basophilic Stippling
      • Example of Fine Basophilic Stippling
      • Coarse Basophilic Stippling
      • Coarse Basophilic Stippling, continued
  • Characteristics of Howell-Jolly Bodies
      • Howell-Jolly Bodies
      • Howell-Jolly Body
      • Another Howell-Jolly Body
      • Howell-Jolly Body in Nucleated Red Cell
  • Characteristics of Pappenheimer bodies and Siderotic granules
      • Pappenheimer Bodies
      • Pappenheimer Bodies, continued
      • Pappenheimer Bodies, continued
      • Basophilic Stippling contrasted with Pappenheimer Bodies
      • Howell-Jolly Bodies and Pappenheimer Bodies
      • Comparison of Erythrocyte Inclusions
      • Siderotic Granules
      • Siderocytes and Ringed Sideroblasts in Bone Marrow
      • Siderocyte
      • Sideroblast
  • Characteristics of Cabot Rings
      • Cabot Rings
      • Cabot Rings, continued
      • Cabot Rings, continued
  • Characteristics of Heinz bodies
      • Heinz bodies
      • Heinz bodies
      • Malaria and Malarial Parasites
  • References
      • References

Additional Information

Level of Instruction: Intermediate

Intended Audience: Medical laboratory personnel including medical laboratory scientists, medical technologists, medical laboratory technicians. Also appropriate for medical laboratory students, and pathology residents.

Course Description: This course identifies, describes, and illustrates red blood cell inclusions as they are observed on Wright or Wright-Giemsa-stained peripheral smears. Additional staining procedures that make possible or enhance identification of some erythrocyte inclusions are also discussed. Numerous practice and exam questions reinforce visual recognition skills.

Prerequisites: Skill in the use of the microscope, aseptic techniques, experience preparing and gram staining smears, and experience reading smears from cultures.

Author Credentials: This course was developed by Betty Smith MT (ASCP) and Jaimy Hill MT (ASCP), and was updated by Education Materials for Health Professionals, Inc., under the supervision of Marjorie Spahn MT(ASCP). It was reviewed and adapted for online use by Paul Fekete, M.D. fellow C.A.P.

Reviewer information: Rory Huschka, M. Ed., MT(ASCP), has over 20 years of combined experience as a medical technologist, technical supervisor, professor, and manager. He is a former Program Director of Clinical Laboratory Science and Medical Laboratory Technician Programs. He is currently a Program Director at MediaLab, Inc. Rory holds a BS degree in Medical Technology from North Dakota State University and a Master's degree in Educational Leadership.

About this Course: This revised course was originally part of a series of courses adapted for the web by MediaLab Inc. under license from Educational Materials for Health Professionals Inc. Dayton OH, 45420. Copyright EMHP Inc.

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