Hereditary Hemochromatosis (by LabCE)

2 P.A.C.E. contact hour(s)

(based on 310 customer ratings)

Author: Rebecca J. Laudicina, PhD, MLS(ASCP)CM
Reviewer: Vicky LeGrys, DA, MLS(ASCP)CM

Course provided by LabCE.

Hereditary hemochromatosis is a disorder of iron regulation that can over time lead to widespread organ damage, a variety of chronic disorders, and even death. Early detection may permit treatment before the development of substantial iron overload. The laboratory technologist plays a major role in detecting and controlling this disease. In this course, you will learn about the basics of iron metabolism, the signs and symptoms of hemochromatosis, how it is treated, and the laboratory tests and procedures that are vital to its diagnosis and maintenance.

See more courses in: Hematology

Included In These Course Packages

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 2 hour(s)
Course number 578-066-20, approved through 8/31/2022
Course number 20-785946, approved through 9/1/2022

Objectives

  • Describe basic aspects of normal iron metabolism.
  • Explain the pathophysiology of iron overload associated with hereditary hemochromatosis (HH).
  • Discuss mutations associated with HH, including prevalence in various ethnic groups and penetrance.
  • List early and late clinical signs and symptoms of HH.
  • Evaluate screening and confirmatory laboratory tests used in detection and diagnosis of iron overload and HH.
  • Describe initial and long-term treatment and management options for HH.

Customer Ratings

(based on 310 customer ratings)

Users Also Bought

12 P.A.C.E.® contact hours
(1 ratings) $44 Add to cart
1 P.A.C.E.® contact hour
(389 ratings) $20 Add to cart
12 P.A.C.E.® contact hours
(1 ratings) $44 Add to cart
1 P.A.C.E.® contact hour
(732 ratings) $20 Add to cart

Course Outline

  • Introduction
      • Introduction
  • Normal Iron Metabolism
      • Overview of Iron Metabolism
      • Storage Iron
      • Iron Intake and Recycling
      • Regulation of Iron Equilibrium
      • Iron Transport
  • Pathophysiology of Iron Overload in HH
      • Altered Iron Absorption
      • Development of Iron Overload
  • Mutations Associated with HH
      • HFE and Other Genes
      • Specific HFE Mutations
      • Epidemiology of HFE Mutations
      • Incomplete Penetrance
      • Prevalence of HFE Mutations
  • Diagnosis
      • General Clinical Considerations
      • Signs and Symptoms of HH
      • Diagnosing HH
      • Example of a Testing Algorithm Using Transferrin Saturation as an Initial Test
  • Laboratory Testing for HH
      • General Overview of Laboratory Testing
      • Serum Iron (SI)
      • Transferrin (Tf) and Total Iron Binding Capacity (TIBC)
      • Transferrin Saturation (TS)
      • Serum Ferritin (SF)
      • Unsaturated Iron Binding Capacity (UIBC)
      • Molecular Tests for Genetic Mutations
      • Definitive Tests for Iron Overload
      • Quantitative Phlebotomy
      • Screening for Hereditary Hemochromatosis
  • Treatment and Management of HH
      • Rationale for Treatment
      • Initial Treatment
      • Maintenance Therapy
      • Other Treatments
      • Prognosis and Mortality
  • Case Study
    • References
        • References

    Additional Information

    Level of instruction: Intermediate

    Intended Audience: Clinical laboratory technologists and technicians, and other health care personnel who have an interest in this subject matter. This course is also appropriate for clinical laboratory science students and pathology residents.
     
    Author Information: Rebecca J. Laudicina, PhD, MLS(ASCP)CM is Professor Emeritus in the Division of Clinical Laboratory Science at The University of North Carolina at Chapel Hill’s School of Medicine. She obtained a Master of Education and PhD in Educational Psychology from Temple University. She is the author of numerous publications including many in the field of hematology. 
      
    Reviewer Credentials: Vicky LeGrys, DA, MLS(ASCP)CM is a professor in the Division of Clinical Laboratory Science in the School of Medicine at the University of North Carolina Chapel Hill where she is responsible for the lecture and laboratory courses in Biochemistry, Clinical Chemistry, and Quality Assurance. She holds a Doctorate of Arts and a Master of Science in Medical Technology from Catholic University of America, Washington DC with a major in Clinical Chemistry.  
     
    Course Description: This course offers an depth look at the condition, hemochromatosis. It begins with a discussion about normal iron metabolism and continues by explaining the pathophysiology of iron overload that occurs in the condition, hemochromatosis. Clinical considerations and laboratory testing are also discussed.

    How to Subscribe
    MLS & MLT Comprehensive CE Package (by LabCE)
    Package of 122 online courses$95
    Add to cart
    Single online course$20
    Add to cart
    • Order for instant access through any computer, any browser.
    • No shipping, faxing, or waiting for certificates.
    • Print or save your certificate of completion as soon as you've completed the course.
    • You'll have 90 days to complete your purchased courses.
    Course provided by LabCE.
    Iron deposits, liver section stained with Prussian blue.  Courtesy of John Woosley, MD.


    Consequences of Iron Overload in HH


    HH Signs & Symptoms


    Iron Metabolism


    Sample Algorithm for HH



     
    ASCLS CE's design and platform are provided by MediaLab, Inc.